2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113723
    MRS2298 491611-43-9 98%
    MRS2298? is a potent acyclic P2Y1 receptor antagonist with a Ki of 29.6 nM. MRS2298 inhibits the ADP-induced aggregation of human platelets with an IC50 of 62.8 nM. MRS2298 inhibits Ca2+ rise in platelets with an IC50 of 810 nM.
    MRS2298
  • HY-113748
    Rev 6207 free base 98056-23-6 98%
    Rev 6207 (free base) is a potent non-thiol angiotensin I converting enzyme inhibitor. Rev 6207 (free base) has comparable antihypertensive activity to Enalapril (HY-B0331) in awake monkeys with high renin activity and can be used in the study of hypertensive diseases.
    Rev 6207 free base
  • HY-113813
    SQ 28853 107550-68-5 98%
    SQ 28853 is an angiotensin converting enzyme (ACE) inhibitor with potent diuretic activity. SQ 28853 can be used for the research of cardiovascular.
    SQ 28853
  • HY-113841
    RS-87337 107707-38-0 98%
    RS-87337 is an orally active antiarrhythmic agent that increases the duration and the maximum rate of rise of cardiac muscle action potentials. RS-87337 is promising for research of antiarrhythmic and cardioprotective agents.
    RS-87337
  • HY-113858
    Brefonalol 103880-26-8 98%
    Brefonalol is a beta-adrenergic receptor blocker. Brefonalol can be used for the research of hypertension, arrhythmias and angina pectoris.
    Brefonalol
  • HY-113892
    Leniquinsin 10351-50-5 98%
    Leniquinsin is a phosphodiesterase inhibitor, which is used as a vasodilator.
    Leniquinsin
  • HY-114638
    Diproteverine 69373-95-1 98%
    Diproteverine (BRL 40015) is an oral activity calcium channel blocker. Diproteverine embryonic toxicity. Diproteverine also shows antianginal properties.
    Diproteverine
  • HY-114674
    A-127722 195704-72-4 98%
    A-127722 is A 2, 4-dialarylpyrrolidine-3-carboxylic acid ETA selective endothelin receptor (ET receptor) antagonist with IC50 value of 0.36 nM.
    A-127722
  • HY-114686
    (R)-γ-Valerolactone 58917-25-2 98%
    (R)-γ-Valerolactone is a precursor of antihypertensive compounds. (R)-γ-Valerolactone can also be used in the research of biodegradable plastics and biofuels.
    (R)-γ-Valerolactone
  • HY-114846
    Ro 22-9194 106134-33-2 98%
    Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action.
    Ro 22-9194
  • HY-114941
    Aladotril 173429-64-6 98%
    Aladotril (BP1137) is the inhibitor for neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE), that ameliorates the cardiac hypertrophy in rats, without decreasing the blood pressure. Aladotril can be used in research about heart failure and cardiac remodeling after myocardial infarction.
    Aladotril
  • HY-114942
    Prostaglandin E1 ethyl ester 35900-16-4 98%
    Prostaglandin E1 ethyl ester (Prostaglandin E1 Et ester) is the esterified form of Prostaglandin E1 (PGE1; HY-B0131). Prostaglandin E1 (Alprostadil) is a prostaglandin receptor ligand that induces vasodilation and inhibits platelet aggregation.
    Prostaglandin E1 ethyl ester
  • HY-115014
    Cibenzoline succinate 100678-32-8 98%
    Cibenzoline succinate (Cifenline succinate) is the succinate form of Cibenzoline (HY-106577). Cibenzoline succinate is an inhibitor for ATP-sensitive potassium (KATP) channel by affecting the pore-forming Kir6.2 subunit with IC50 of 22.2 µM. Cibenzoline succinate affects insulin secretion and exhibits antiarrhythmic and antidiabetic activities.
    Cibenzoline succinate
  • HY-115381
    Lipoxin A5 110657-98-2 98%
    Lipoxin A5 is an eicosapentaenoic acid derived from pig white blood cells. Lipoxin A5 slowly contracted the guinea pig lung parenchymal strips with a contractile force similar to that of LXA4 and LXB4.2, but LXA5 did not have the vasodilating effect on the aortic smooth muscle shown by LXA4 and LXB4.2.
    Lipoxin A5
  • HY-115474
    Cardionogen-2 578755-52-9 98%
    Cardionogen-2 is a biphasic modulator of cardiogenesis, either promoting or inhibiting heart formation depending on the stage of treatment. Cardionogen-2 inhibits Wnt/β-catenin-dependent transcription in murine embryonic stem (ES) cells and zebrafish embryos.
    Cardionogen-2
  • HY-115862
    Benzo[c][1,8]naphthyridin-6(5H)-one 53439-81-9 98%
    Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM.
    Benzo[c][1,8]naphthyridin-6(5H)-one
  • HY-116072
    Antiarrhythmic agent-2 105919-73-1 98%
    Antiarrhythmic agent-2 is a nonspecific Ca2+ inward current blocker that inhibits ionic currents in sensory neuron membranes. Antiarrhythmic agent-2 can be used in the study of cardiovascular diseases, such as arrhythmias.
    Antiarrhythmic agent-2
  • HY-116150
    Xymedon 14716-32-6 98%
    Xymedon is a pyrimidine derivative with anti-atherosclerotic effects. Xymedon reducts plasma cholesterol levels and cholesterol esterification in blood vascular cells.
    Xymedon
  • HY-116262
    SCH 51866 167298-74-0 98%
    SCH 51866 is a potent, selective and orally active inhibitor of PDE1 (IC50=70 nM) and PDE5 (IC50=60 nM). SCH 51866 inhibits collagen-induced aggregation of human washed platelets (IC50=10 μM), prevents neointimal formation in balloon catheter-injured carotid arteries of spontaneously hypertensive rats (SHR), and reduces blood pressure in SHR. SCH 51866 can be used in the study of hypertension.
    SCH 51866
  • HY-116281
    ICI D1542 147332-48-7 98%
    ICI D1542 is a selective and potent inhibitor of thromboxane A2 (TXA2) synthase and the thromboxane A2 receptor (TP-receptor). ICI D1542 is effective at preventing thrombus formation by redirection of arachidonic acid metabolism.
    ICI D1542
Cat. No. Product Name / Synonyms Application Reactivity